Publications

Rao X, Allison DB; Flight RM, Lin P, Cassel T, Wu Y; Scott T, He D, Li Z, Zhang Y, Wang R, Li C, Wang X, Wang J, Ali ES, Shao Q, Wang C, Moseley HNB, Liu X. (2024) PLK1 phosphorylation of PHGDH reprograms serine and lipid metabolism to drive tumor progression. Submitted.

Lemberg KM, Ali ES, Krecmerova M, Aguilar JMH, Alt J, Peters DE, Zhao L, Wu Y, Nuha N, Asara JM, Staedtke V, Pratilas CA, Majer P, Rais R, Ben-Sahra I, Slusher BS. Pro-905, a Novel Purine Antimetabolite, Combines with Glutamine Amidotransferase Inhibition to Suppress Growth of Malignant Peripheral Nerve Sheath Tumor. Molecular Cancer Therapeutics. 2023 Dec 1;22(12):1390-1403. Highlighted on Onco'Zine, ScienceDaily, Hopkins Medicine Newsroom. 

Ali ES, Chakrabarty B, Ramproshad S, Mondal B, Kundu N, Sarkar C, Sharifi-Rad J, Calina D, Cho WC. TRPM2-mediated Ca2+ signaling as a potential therapeutic target in cancer treatment. Cell Communication and Signaling. 2023 Jun 19;21(1):145.

Ali ES, Ben-Sahra I. Regulation of nucleotide metabolism in cancers and immune disorders. Trends in Cell Biology. 2023 Nov;33(11):950-966. 

Perrault EN, Shireman JM, Ali ES, Lin P, Preddy I, Park C, Budhiraja S, Baisiwala S, Dixit K, James CD, Heiland DH, Ben-Sahra I, Pott S, Basu A, Miska J, Ahmed AU. Ribonucleotide reductase regulatory subunit M2 drives glioblastoma TMZ resistance through modulation of dNTP production. Science Advances. 2023 May 19;9(20):eade7236. Highlighted on Feinberg News Center. 

Ali ES, Mitra K, Akter S, Ramproshad S, Mondal B, Khan IN, Islam MT, Sharifi-Rad J, Calina D, Cho WC. Recent advances and limitations of mTOR inhibitors in the treatment of cancer. Cancer Cell International. 2022 Sep 15;22(1):284. 

Ali ES, Lipońska A, O'Hara BP, Amici DR, Torno MD, Gao P, Asara JM, Yap MF, Mendillo ML, Ben-Sahra I. The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis. Molecular Cell. 2022 Sep 1;82(17):3284-3298.e7.  Commentary: Koe et al. (2022) Molecular Cell. Highlighted on Feinberg News Center and MedicalXpress.

Ali ES, Akter S, Ramproshad S, Mondal B, Riaz TA, Islam MT, Khan IN, Docea AO, Calina D, Sharifi-Rad J, Cho WC. Targeting Ras-ERK cascade by bioactive natural products for potential treatment of cancer. Cancer Cell International. 2022 Aug 8;22(1):246. 

Soflaee MH, Kesavan R, Sahu U, Tasdogan A, Villa E, Djabari Z, Cai F, Tran DH, Vu HS, Ali ES, Rion H, O'Hara BP, Kelekar S, Hallett JH, Martin M, Mathews TP, Gao P, Asara JM, Manning BD, Ben-Sahra I, Hoxhaj G. Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway. Nature Communications. 2022 May 16;13(1):2698. 

Ali ES, Barua D, Saha SK, Ahmed MU, Mishra SK, Mubarak MS. Targeting redox signaling and ROS metabolism in cancer treatment. In Book: Handbook of Oxidative Stress in Cancer: Mechanistic Aspects, 2022, Springer, eBook ISBN978-981-15-4501-6. 

Ali ES, Rychkov GY, Barritt GJ. TRPM2 Non-Selective Cation Channels in Liver Injury Mediated by Reactive Oxygen Species. Antioxidants (Basel). 2021 Aug 3;10(8). 

Islam MT, Quispe C, Islam MA, Ali ES, Saha S, Asha UH, Mondal M, Razis AFA, Sunusi U, Kamal RM, Kumar M, Sharifi-Rad J. Effects of nerol on paracetamol-induced liver damage in Wistar albino rats. Biomedicine and Pharmacotherapy. 2021 Aug;140:111732. 

Ali ES, Girard D, Petrovsky N. Impaired Ca(2+) signaling due to hepatic steatosis mediates hepatic insulin resistance in Alström syndrome mice that is reversed by GLP-1 analog treatment. American Journal of Physiology-Cell Physiology. 2021 Jul 1;321(1):C187-C198. 

Villa E, Sahu U, O'Hara BP, Ali ES, Helmin KA, Asara JM, Gao P, Singer BD, Ben-Sahra I. mTORC1 stimulates cell growth through SAM synthesis and m(6)A mRNA-dependent control of protein synthesis. Molecular Cell. 2021 May 20;81(10):2076-2093.e9. Commentary by Sunil Shetty and Michael Hall in Molecular Cell. Highlighted on Feinberg News Center and MedicalXpress.

Shireman JM, Atashi F*, Lee G*, Ali ES*, Saathoff MR, Park CH, Savchuk S, Baisiwala S, Miska J, Lesniak MS, James CD, Stupp R, Kumthekar P, Horbinski CM, Ben-Sahra I, Ahmed AU. De novo purine biosynthesis is a major driver of chemoresistance in glioblastoma. Brain. 2021 May 7;144(4):1230-1246. Highlighted on Feinberg News Center and MedicalXpress.

Ali ES, Rychkov GY, Barritt GJ. Targeting Ca(2+) Signaling in the Initiation, Promotion and Progression of Hepatocellular Carcinoma. Cancers (Basel). 2020 Sep 24;12(10). 

Ali ES*, Sahu U*, Villa E, O'Hara BP, Gao P, Beaudet C, Wood AW, Asara JM, Ben-Sahra I. ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine Synthesis. Molecular Cell. 2020 Jun 18;78(6):1178-1191.e6. Selected as one of the groundbreaking discoveries at Northwestern Medicine during the pandemic [Link], and highlighted on Northwestern Medicine News Center.

Islam MT, Ali ES, Khan IN, Shaw S, Uddin SJ, Rouf R, Dev S, Saravi SSS, Das N, Tripathi S, Yele SU, Das AK, Shilpi JA, Mishra SK, Mubarak MS. Anticancer Perspectives on the Fungal-Derived Polyphenolic Hispolon. Anticancer Agents in Medicinal Chemistry. 2020;20(14):1636-1647. 

Ali ES, Rychkov GY, Barritt GJ. Deranged hepatocyte intracellular Ca(2+) homeostasis and the progression of non-alcoholic fatty liver disease to hepatocellular carcinoma. Cell Calcium. 2019 Sep;82:102057. Highlighted on Flinders Medicine News Desk.  

Villa E*, Ali ES*, Sahu U*, Ben-Sahra I. Cancer Cells Tune the Signaling Pathways to Empower de Novo Synthesis of Nucleotides. Cancers (Basel). 2019 May 17;11(5). 

Paz MFCJ, Gomes Júnior AL, de Alencar MVOB, Tabrez S, Islam MT, Jabir NR, Oves M, Alam MZ, Asghar MN, Ali ES, da Conceição Machado K, da Conceição Machado K, da Silva FCC, Sobral ALP, de Castro E Sousa JM, de Moraes GP, Mishra SK, da Silva J, de Carvalho Melo-Cavalcante AA. Effect of Diets, Familial History, and Alternative Therapies on Genomic Instability of Breast Cancer Patients. Applied Biochemistry and Biotechnology. 2019 May;188(1):282-296. 

Ali ES, Petrovsky N. Calcium Signaling As a Therapeutic Target for Liver Steatosis. Trends in Endocrinology and Metabolism. 2019 Apr;30(4):270-281 

Paz MFCJ, Gomes AL Júnior, Islam MT, Tabrez S, Jabir NR, Alam MZ, Machado KC, de Alencar MVOB, Machado KC, Ali ES, Mishra SK, Gomes LF, Sobral ALP, E Sousa JMC, de Souza GF, Melo-Cavalcante AAC, da Silva J. Assessment of chemotherapy on various biochemical markers in breast cancer patients. Journal of Cellular Biochemistry. 2018 Mar;119(3):2923-2928. 

Tam KC, Ali E, Hua J, Chataway T, Barritt GJ. Evidence for the interaction of peroxiredoxin-4 with the store-operated calcium channel activator STIM1 in liver cells. Cell Calcium. 2018 Sep;74:14-28. doi: 10.1016/j.ceca.2018.05.002. Epub 2018 May 15. PubMed PMID: 29804005.

Islam MT*, Ali ES*, Uddin SJ, Islam MA, Shaw S, Khan IN, Saravi SSS, Ahmad S, Rehman S, Gupta VK, Găman MA, Găman AM, Yele S, Das AK, de Castro E Sousa JM, de Moura Dantas SMM, Rolim HML, de Carvalho Melo-Cavalcante AA, Mubarak MS, Yarla NS, Shilpi JA, Mishra SK, Atanasov AG, Kamal MA. Andrographolide, a diterpene lactone from Andrographis paniculata and its therapeutic promises in cancer. Cancer Letters. 2018 Apr 28;420:129-145.

Paz MFCJ, de Alencar MVOB, Gomes Junior AL, da Conceição Machado K, Islam MT, Ali ES, Shill MC, Ahmed MI, Uddin SJ, da Mata AMOF, de Carvalho RM, da Conceição Machado K, Sobral ALP, da Silva FCC, de Castro E Souza JM, Arcanjo DDR, Ferreira PMP, Mishra SK, da Silva J, de Carvalho Melo-Cavalcante AA. Correlations between Risk Factors for Breast Cancer and Genetic Instability in Cancer Patients-A Clinical Perspective Study. Frontiers in Genetics. 2017;8:236.

Ali ES, Rychkov GY, Barritt GJ. Metabolic Disorders and Cancer: Hepatocyte Store-Operated Ca(2+) Channels in Nonalcoholic Fatty Liver Disease. Advances in Experimental Medicine and Biology. 2017;993:595-621.

Ali ES, Hua J, Wilson CH, Tallis GA, Zhou FH, Rychkov GY, Barritt GJ. The glucagon-like peptide-1 analogue exendin-4 reverses impaired intracellular Ca(2+) signalling in steatotic hepatocytes. Biochim Biophys Acta Molecular Cell Research. 2016 Sep;1863(9):2135-46.

Ali ES, Rajapaksha H, Carr JM, Petrovsky N. Norovirus drug candidates that inhibit viral capsid attachment to human histo-blood group antigens. Antiviral Research. 2016 Sep;133:14-22.

Wilson CH*, Ali ES*, Scrimgeour N, Martin AM, Hua J, Tallis GA, Rychkov GY, Barritt GJ. Steatosis inhibits liver cell store-operated Ca²⁺ entry and reduces ER Ca²⁺ through a protein kinase C-dependent mechanism. Biochemical Journal. 2015 Mar 1;466(2):379-90. 

Lundborg M, Ali ES, Widmalm G. An in silico virtual screening study for the design of norovirus inhibitors: fragment-based molecular docking and binding free energy calculations. Carbohydrate Research. 2013 Aug 30;378:133-8